MC1R and neoplasm: Several of the genes described here can be assigned to categories that are involved in the development of solid tumors: MC1R is involved in pigmentation/UV protection [27,28], EPB41 [29,30,31,32,33,34] and MYCT [35,36,37,38] in tumor suppression, and ADGRG3 in immunomodulation [39,40,41,42].