Further, novel therapy leveraging the cyclic GMP-AMP synthase/stimulator of interferon genes (cGAS/STING) signaling pathway, inhibiting the tumor-growth receptor CD73, or enhancing pyroptosis of melanoma cells through gasdermin activation are all potentially promising targets of immunotherapy in melanoma [57,58,59,60,61,62,63]. The gene discussed is CGAS; the disease is melanoma.