Furthermore, increased expression of NF-kB1 is linked to poor survival rates and the development of chemo/radiation resistance in many malignant neoplasms, including rectal cancer, kidney cancer, GC, etc. The results showed that the NF-κB1 gene is also a predictive and prognostic marker in the treatment of cancers [129]. This evidence concerns the gene NFKB1 and rectal cancer.