The Aldo-Keto Reductase Family 1 Member B10 (AKR1B10), a unique tumor biomarker that is overexpressed in BC, stimulates the NF-κB pathway by inducing PI3K/AKT signaling and enhances the expression levels of ZEB1, Slug, and Twist, promoting EMT induction and increasing breast tumor cell dissemination. Here, AKR1B10 is linked to breast neoplasm.