We employed two experimental models of HNSCC to better characterize the specific immunological responses associated with T cell stimulation using the IR HNSCC tumor antigen: (i) LY2 HNSCC cells injected into STAT1-deficient BALB/c mice [20,22] and (ii) MOC2 HNSCC cells injected into wild-type C57BL/6 mice [21,37,38]. Here, STAT1 is linked to head and neck squamous cell carcinoma.