The importance of anemia as a risk factor in MF is evidenced by the fact that Hb < 10 g/dL is included in the IPSS, DIPSS/DIPSS-plus, and MIPSS70/MIPSS70-plus v.2.0 prognostic models; and sex- and severity-adjusted Hb levels are incorporated in the MIPSS70-plus v.2.0 [80]. Here, GSTM1 is linked to anemia.