U2AF1 and anemia: Consistent with the aforementioned studies, spliceosome U2AF1 mutations have been associated with the myelodepletive phenotype [11], severe anemia and thrombocytopenia, and smaller spleen size [25,60,61]; in particular, mutation U2AF1 Q157 was associated with thrombocytopenia, anemia, and significantly shorter survival [61].