JAK2 and Thrombocytopenia: Similarly, thrombocytopenia was associated with low JAK2 V617F VAF (p < 0.01), presence of U2AF1 Q157 (p < 0.01), and ≥3 non-driver mutations (p < 0.01); harboring SRSF2 or TP53 significantly shortened OS in a large cohort of MF patients (with platelet counts <100 × 109/L) [62].