Along these lines, JHU083, a small molecule inhibiting glutamine catabolism along with OXPHOS induces apoptosis in both the tumor and in the circulation, thus improving the anti-tumor immunity in mice through different mechanisms, including the increase in the anti-tumor Th1 frequency, the upregulation of the IL2-STAT/mTORC1/Myc signaling pathways coupling with the glutamine downregulation, and the inhibition of the Th17 pro-tumor cells [173]. This evidence concerns the gene MYC and neoplasm.