IFNγ and GM-CSF in the TME promote the maturation of immature neutrophils into APCs expressing HLA-DR and the co-stimulatory molecules CD86, 4-1BB ligand (4-1BBL), and OX40 ligand (OX40L), and are capable in amplifying the anti-tumor response mediated by the T cells [145]. The gene discussed is TNFSF4; the disease is neoplasm.