ACKR2 and breast carcinoma: In an orthotopic transplantation model of breast cancer and a genetically engineered mouse model of oncogene-driven mammary carcinogenesis, the mobilization of neutrophils into the metastatic lung was regulated by the atypical chemokine receptor 2 (ACKR2), a decoy and scavenger receptor that is capable of binding the majority of inflammatory CC-chemokines expressed in early hematopoietic precursors [89].