SLC27A2 and breast cancer: Consistently, circulating PMN-MDSCs from the head and neck, lung, or breast cancers accumulate more lipids than PMNs from healthy controls and can upregulate the fatty acid transport protein 2 (FATP2) involved in the uptake of arachidonic acid, and in the subsequent synthesis of prostaglandin E2 (PGE2), which, in turn, supports tumor growth and immune evasion [169].