To investigate whether ADCC, mediated by DB against NB cells, impacts on the expression of TIGIT and CD226 on effector cells, with a special focus on NK cells as a major cell population mediating ADCC, as well as CD112 and CD155 on GD2-positive tumor cells (LAN-1), flow cytometry analysis of both effector and tumor cells, harvested after the induction of ADCC, was performed. This evidence concerns the gene PVR and neuroblastoma.