Based on the fact that, besides TIGIT and its ligands, DB-ADCC also strongly induced the expression of the PD-1/PD-L1 pathway [6], and on the fact that the expression of both immune checkpoints has been shown to be coupled [13], we investigated here the anti-NB efficacy of a combinatorial treatment strategy with the chimeric anti-GD2 Ab DB in combination with the double immune checkpoint blockade. This evidence concerns the gene CD274 and neuroblastoma.