Although NB belongs to the “cold” tumors (low levels of neo-antigens, low MHC-I expression) and immune checkpoint inhibitors would not be effective as single-agent treatments, we previously showed a significant induction of both PD-L1 and PD-1 expression on NB and effector cells, respectively, after the induction of anti-GD2 ADCC with DB [6]. Here, CD274 is linked to neuroblastoma.