TP53 and breast carcinoma: While there is a consensus that the genes to be screened to predict the individual risk for breast cancer in diagnostic setting should be BRCA1, BRCA2, PALB2, TP53, BARD1, RAD51C, RAD51D, ATM and CHEK2, other predisposing genes, such as FANCM, are yet to be validated [12].