Moreover, the neuroblastoma cell lines have been used in a wide spectrum of studies on genetic, biochemical, functional, and structural neuroblastoma characteristics, for example on the interaction of neuroblastoma cells with Schwann cells, the synthesis of neurotransmitters, differentiation and transdifferentiation processes, chromosomal structure, the role of MYCN expression, the importance of neuropeptide Y and hypoxia, and many others [57,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83]. This evidence concerns the gene NPY and neuroblastoma.