Interestingly, subsequent research has demonstrated that HuR is necessary for the METTL3-mediated stabilisation of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), which in turn activates nuclear factor kappa B (NFB) in isocitrate dehydrogenase (IDH) wildtype glioma [50]. This evidence concerns the gene IDH1 and central nervous system cancer.