We identified several proteins previously reported in ESCC including PDPN, POSTN, TOP2A, MMP12, UBE2C and PLAU, which were overexpressed and CRNN, SPRR3, SORBS2, RHCG, ECM1, and TGM3, which were downregulated. Here, SPRR3 is linked to esophageal squamous cell carcinoma.