Another study on quantitative tissue proteomic analysis of high-grade esophageal squamous intraepithelial neoplasia (HGIN), a precancerous lesion of ESCC, identified proteins IGF2BP3, NUP188, and MOCS3 overexpressed in HGIN, suggesting their potential involvement in the development of ESCC [17]. This evidence concerns the gene IGF2BP3 and esophageal squamous cell carcinoma.