We identified several proteins previously reported in ESCC including PDPN, POSTN, TOP2A, MMP12, UBE2C and PLAU, which were overexpressed and CRNN, SPRR3, SORBS2, RHCG, ECM1, and TGM3, which were downregulated. The gene discussed is PDPN; the disease is esophageal squamous cell carcinoma.