It has also been reported that these interactions are involved in the glioma pathogenesis through numerous mechanisms, including those mediated by Bcl-2-modifying factor (BMF), Forkhead box protein O1 (FOXO1), B-cell lymphoma 2 (BCL2), Bcl-2-associated X protein (BAX), plexin-C1 (PLXNC1), cofilin, phosphotyrosine interaction domain-containing protein 1 (PID1), migration and invasion inhibitory protein (MIIP), SIRT1, PI3K, AKT, MEK, ERK, and PTEN. The gene discussed is PTEN; the disease is central nervous system cancer.