Considering the circulating miRNAs as a promising diagnostic biomarker for human glioma, which can be used for early detection, Cai et al. [171] demonstrated an inverse association during adult glioma progression between miR-124-3p and RAS homology growth-related (RHOG) expression levels progression in glioblastoma multiforme tissues and cells. This evidence concerns the gene RHOG and central nervous system cancer.