The overexpression of miR-4476 was found to be an unfavorable prognostic factor and was correlated with the expression of the c-Jun proto-oncogene, but negatively correlated with the expression of APC, concluding that miR-4476 works as a tumor enhancer, which can stimulate its own expression and furtherly promote the malignant phenotypes of gliomas [150]. The gene discussed is APC; the disease is central nervous system cancer.