The authors reported that GAS5 significantly down-regulated miR-10b and also reduced the expression of sirtuin 1 (SIRT1), thereby hindering the phosphorylation of each of protein kinase B (AKT), mitogen-activated protein kinase (MEK), phosphoinositide 3-kinase (PI3K) and extracellular signal-regulated kinase (ERK), leading to increase the expression of phosphatase and tensin homolog (PTEN) gene and inhibit glioma proliferation. This evidence concerns the gene AKT1 and central nervous system cancer.