A recent sub-study by Ryu et al., 2021 [289], from a prospective, randomized phase III clinical trial of seven centers, was conducted with 123 HER2-negative breast cancer patients and identified differences in the metabolic and immunologic profiles as well as NLRs in patients treated with neoadjuvant chemotherapy (NCT) or neoadjuvant endocrine therapy (NET). The gene discussed is ERBB2; the disease is breast cancer.