Interestingly, gene polymorphism (C/C genotype) in MMP2 (rs243865) was associated with the progression of anthracycline-induced CHF with a significant decrease in LVEF by 13.2% (from 50% (47,52) to 43% (35; 49)) and increased in end-systolic and end-diastolic dimension by 7.7% (p < 0.001) and 4.0% (p < 0.001), respectively. The gene discussed is MMP2; the disease is congestive heart failure.