A recent search on the Exome Variant Server (https://evs.gs.washington.edu/EVS/ (accessed on 16 March 2023) reveals a total of 67 missense SNPs in the ERBB2 gene; however, their role in the therapeutic efficacy and response in patients with HER2 breast cancer remains to be elucidated. This evidence concerns the gene ERBB2 and breast cancer.