Regarding AML with recurrent genetic abnormalities, from a historical point of view, the most obvious prognostic value is illustrated by APL, related to PML-RAR translocation, which confers, even for high-risk APL, an excellent prognosis with a 2-year DFS and OS of 94% and 100% in an intention-to-treat analysis [5]. Here, PML is linked to acute promyelocytic leukemia.