In AML with t(6;9)(p22.3;q34.1)/DEK::NUP214, the translocation can involve the two proto-oncogenes SET and DEK, resulting in a SET-NUP214 and DEK-NUP214 chimeras, whose pathophysiological mechanism relies on the properties of the resulting fusion protein. The gene discussed is NUP214; the disease is acute myeloid leukemia.