Regarding the molecular subtypes, some differences exist, such as a defined section of AML with nucleoporin (NUP)98 rearrangement, RNA-binding motif protein 15 (RBM15), myocardin-related transcription factor-A (MRTFA) fusion, or other fusion genes than Myeloid/Lymphoid or mixed-lineage Leukemia, translocated to 3 (MLLT3) associated to lysine N-methyltransferase 2A (KTM2A) in the ICC classification, which, in contrast, is absent in the WHO classification. This evidence concerns the gene NUP98 and acute myeloid leukemia.