Beyond T-cells, Caspase-8 deficiency has been also linked to impaired S-phase entry in hepatocytes stimulated with epidermal growth factor (EGF) [59] and in which Caspase-8 knockdown in MDA-MB-231 breast cancer cells dramatically reduces cell proliferation, despite having little influence on cell viability [8,60]. This evidence concerns the gene EGF and breast cancer.