It has been demonstrated that, upon EGF stimulation, Caspase-8 and active Src co-immunoprecipitate, also suggesting a role for Tyr380 in this context [87], and the existence of a crosstalk between receptor and non-receptor tyrosine kinase signaling and Caspase-8, especially in pathological contexts such as cancer; however, the precise mechanism deserves further elucidation. The gene discussed is CASP8; the disease is cancer.