Gopalakrishnan et al. [12] observed a significant positive correlation between the relative abundance of Faecalibacterium and the frequencies of tumor CD8+ T cell infiltrate and peripheral CD8+ T cell and effector CD4+ T cell, as well as a positive association with peripheral cytokine profile for response to ICI treatment, highlighting a positive immunomodulatory effect of this bacterial genus. The gene discussed is CD4; the disease is neoplasm.