In addition, polyphenols extracted from the green pea hulls could also ameliorate colitis in C57BL/6 male mice by activating the Kelch-like ECH-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2)-antioxidant responsive element (ARE) signaling pathway, regulating gut microbiota, and increasing the levels of short-chain fatty acids (SCFAs). This evidence concerns the gene NFE2L2 and colitis.