For instance, in a mouse model of cMyBP-C cardiomyopathy, both cardiomyocyte hypertrophy and myocardial fibrosis could be prevented or attenuated by deleting a key TGF-β receptor (Tgfbr2) in myofibroblasts [62]. The gene discussed is TGFBR2; the disease is Myocardial fibrosis.