Osteodysplastic primordial dwarfism type 2 (MOPD2): Severe intrauterine growth retardation with proportionate microcephaly, mesomelia (shortness of the middle portion of a limb), skeletal dysplasia, abnormal dentition, insulin resistance, and cerebral vascular disease with progressive stenosis and occlusion of the cerebral arteries and moyamoya disease. Here, INS is linked to microcephalic osteodysplastic primordial dwarfism type II.