KEGG analysis for pathway enrichment and functions commonly altered in TM4 Sertoli cells and PND8 rat Sertoli cells exposed to 50 μM APAP + GEN mixture highlighted terms including viral carcinogenesis, necroptosis, transcriptional misregulation in cancer, the p53 signaling pathway, cellular senescence, the TNF-signaling pathway, and pathway involving protein interaction with cytokine and a cytokine receptor (Table 3). Here, TNF is linked to cancer.