Among upregulated genes, the gene Greb1 (growth regulating estrogen receptor binding 1), which is regulated by Esr1 in TM4 cells and primary Sertoli cells [36] and is involved in hormone-responsive breast and prostate cancers, was increased by 3.5-fold only by the APAP + GEN mixture. Here, ESR1 is linked to Familial prostate cancer.