LRRK2 and Alzheimer disease: Specifically, we found that LRRK2 kinase inhibition with MLi2 and PF-06447475 (PF) attenuated neuroinflammation, gliosis and cell toxicity in mice with intracerebral injection of Aβ1-42 fibrils (our AD mouse model) or of α-syn preformed fibrils (pffs; our PD mouse model).