ACHE and obesity due to melanocortin 4 receptor deficiency: Moreover, acetylcholine (ACh), which is globally elevated in anxiety states [106], can block NFκB-mediated inflammation [12,107]; and transgenic excess of the acetylcholinesterase-targeting miR-132 [108], which exacerbates anxiety [109] by limiting acetylcholinesterase (which would elevate acetylcholine levels and further reduce inflammation), induces obesity [110].