The long RNA sequencing of the larval anxiety and obesity models revealed that as many as 75% of the genes (including lincRNAs) common to both models that were upregulated in anxiety were also downregulated in obesity, and these inversely regulated DE genes were overrepresented in the following immune system-related pathways: (1) “CCKR signaling map (gastrin- and cholecystokinin-mediated regulation of cellular processes)”, (2) “inflammation mediated by chemokine and cytokine signaling pathway”, and (3) “interleukin signaling pathway”. This evidence concerns the gene GAST and obesity due to melanocortin 4 receptor deficiency.