Most notable among the anxiety-upregulated and obesity-downregulated terms were the immune-related protein class, “basic leucine zipper transcription factor” (involved in the development of immune cells [75]), and the three immune system-related pathways: “inflammation mediated by chemokine and cytokine signaling pathway”, “CCKR (gastrin- and cholecystokinin-mediated regulation of cellular processes) signaling map”, and the “interleukin signaling pathway” (Figure 2A). This evidence concerns the gene GAST and obesity due to melanocortin 4 receptor deficiency.