As previously reported, HIF-1α increases the expression of a wide range of immune checkpoints such as CTLA-4 on T cells; LAG3, TIM3, and PD-L1 on tumor cells; and PD-L1 and VISTA on MDSCs, thus resulting in the inhibition of T cell proliferation and T cell-mediated lysis. This evidence concerns the gene CD274 and neoplasm.