CD274 and central nervous system cancer: For high-grade gliomas, an intravenous infusion of the oncolytic human Orthoreovirus in patients could increase the cytotoxic T cell infiltration within the tumors, IFN gene expression, and expression of PD-1 and PD-L1, thus suggesting that the combination of this reovirus with PD-1/PD-L1 blockade could lead to significant clinical benefits [70].