Although each subtype of APC is responsible for different functions in the immune response, the type-1 DCs (cDC1s) are the most important for the anti-tumor immune response because they are responsible for inducing anti-tumor CD8 T cell responses after the presentation of tumor antigens via the class I major histocompatibility complex (MHC-I) [13]. This evidence concerns the gene CD8A and neoplasm.