PLCG2, FABP4, and LGALS1, which are involved in inflammatory pathways as well as pathways regarding leukocyte transendothelial migration, vascular smooth muscle contraction, and the pro-inflammatory PPAR signalling pathways that were upregulated were also upregulated in scleroderma ECs (Figure 5) [78,79,80]. This evidence concerns the gene PLCG2 and scleroderma.