The few effector molecules that were identified, including NTN1, VEGFD, MMP2, FGF2, and FNDC5, provide evidence for the anti-fibrotic and anti-inflammatory effects of the ADSC secretome (Figure 8); however, these few factors cannot explain all observed effects on scleroderma skin after autologous fat grafting. Here, FNDC5 is linked to scleroderma.