Genes associated with ECM components, such as COL4A1, heparan sulfate proteoglycan 2 (HSPG2), and actin beta (ACTB), as well as phospholipase C gamma 2 (PLCG2), fatty binding protein 4 (FABP4), and galectin 1 (LGALS1), also showed higher expression levels in scleroderma. This evidence concerns the gene PLCG2 and scleroderma.