KRT25 and hypotrichosis simplex: In addition, some paralog genes Krt25, Krt27, Krt72, Krt75, and Krt85, which also participate in the formation of keratin intermediate filaments in the IRS, could be related to Woolly Hair, Autosomal Recessive 3, and Hypotrichosis 8, which were significantly decreased in Krt71–KO mice (Figure 3A–E).