In contrast, YAP1, a downstream effector of Hippo signaling regulating proliferation, survival, and organogenesis in mammalian cells, that can also be activated through SRC-mediated gp130 activation in cardiomyocytes [276], is involved in cardio-protective mechanisms against pressure overload stimulation of cardiac hypertrophy (Figure 2). This evidence concerns the gene YAP1 and cardiac hypertrophy.