Interestingly, the use of antibodies that hamper the CD93/MMRN2 interaction significantly reduced vascular sprouting in the human choroidal endothelial cells, demonstrating that the interaction of CD93 with Multimerin-2 plays a key role in pathological vascularization of the choroid, suggesting new therapeutic approaches in the treatment of AMD [67]. Here, CD93 is linked to age-related macular degeneration.