CD93 and hypertensive disorder: Regarding the SNPs of CD93, it has been reported that the SNP rs2749812 of CD93 was associated with a significantly higher cardiovascular risk [61] and the presence of hypertension at high-altitudes [118], while the SNP rs3746731 of CD93 gene was also associated with an increased risk of developing coronary heart disease after adjustment for hypertension, diabetes mellitus, BMI, plasma HDL cholesterol and plasma triglyceride levels [24].