Accordingly, in the present study, we found that ASIV increased the expression of ALDH2 and inhibited autophagy by activating the AKT/mTOR pathway in the mitigation of renal fibrosis, which was further validated by small RNA interference to knock down ALDH2 in TGF-β-induced HK-2 cells. The gene discussed is TGFB1; the disease is renal fibrosis.