AKT1 and renal fibrosis: In summary, the results of this study show that ASIV effectively treats renal fibrosis by alleviating EMT procession and G2/M arrest in vivo and in vitro, and this may be due to the ASIV-induced upregulation of the expression of ALDH2, which inhibits autophagy by regulating the AKT/mTOR pathway (Figure 9).