In addition, TanCAR-redirected T cells targeting IL-13Rα2 or EphA2 in a xenograft mouse model, after subcutaneous injection of U87 glioma cells, were able to elicit greater tumor regression than single CAR-T cells with the potential for reduction of antigen escape and off-target cytotoxicity [41]. Here, IL13RA2 is linked to central nervous system cancer.