In addition, TanCAR-redirected T cells targeting IL-13Rα2 or EphA2 in a xenograft mouse model, after subcutaneous injection of U87 glioma cells, were able to elicit greater tumor regression than single CAR-T cells with the potential for reduction of antigen escape and off-target cytotoxicity [41]. This evidence concerns the gene EPHA2 and central nervous system cancer.