EGFR and neoplasm: Intraventricular injection with CAR-T-EGFRvIII.BiTE-EGFR cells not only induced complete and durable responses associated with prolonged survival in an orthotopic mouse model that received tumor cells of the human glioma U87 and U251 cell lines, as well as in PDXs, but also redirected non-specific bystander T cells and Tregs to become cytotoxic killers without on-target/off-tumor activity [37,38].