When stimulated with LPS and synthetic Amyloid-β42 (Aβ), AD patient monocytes exhibit increased expression of the proteins involved in the assembly, activation, and downstream effectors of inflammasomes, including NLRP1, NLRP3, ASC, caspase-1, -5 and -8, IL-1β and IL-18 [174]. This evidence concerns the gene NLRP1 and Alzheimer disease.