MNX1 and amyotrophic lateral sclerosis: The authors isolated EVs from human-induced astrocytes derived from C9ORF72-ALS sALS patients (C9ORF72-ALS iAstrocyte-derived EVs) and found that they originally compromised both neurite network maintenance and MN survival in HB9-GFP+ mouse-cultured MNs (Hb9-GFP + MNs).