SOD1 and amyotrophic lateral sclerosis: Among the several genes identified as ALS-related, some are involved in both fALS and sALS, such as TDP-43 (TAR DNA-binding protein 43), also known as TARDBP (transactive response DNA-binding protein), SOD1 (copper zinc superoxide dismutase 1), C9ORF72, and FUS (fused in sarcoma), among others [41].