For example, exosomes derived from adipose-derived stem cells (ASCs) obtained from SOD1-G93A mice were shown to have a neuroprotective effect by reducing oxidative stress-related damage in MN-like NSC-34 cells overexpressing ALS-associated mutations, including SOD1(G93A), SOD1(G37R), and SOD1(A4V) [336]. Here, SOD1 is linked to amyotrophic lateral sclerosis.