Regarding the demonstrated growth inhibitory effect of JZL184 on A549 xenografts, our results are in good agreement with data from other authors who reported the tumor-regressive properties of JZL184 in a mouse xenograft model with MAGL-overexpressing hepatocellular cancer cells [25] or in a colon cancer cell xenograft model [24]. Here, MGLL is linked to hepatocellular carcinoma.