LIPA and neoplasm: To further elucidate the role of endogenous 2-AG as a modulator of the angiogenic properties of endothelial cells in the context of tumor–endothelial interaction, it was then investigated whether inhibition of 2-AG synthesis by blocking diacylglycerol lipase (DAGL), the major enzyme for 2-AG synthesis [33], leads to the promotion of angiogenesis.