The interactions of miRNAs, as hsa-let7b/i, hsa-miR-221/222-3p, hsa-miR-302c, hsa-miR-181a, hsa-miR-331 with their potential gene-targets HMGA2, IGF2BP3, STARD4, and APOL6, if functionally validated, could be proven important players for establishing iMSCs as a source for cell therapy in osteoarthritis. This evidence concerns the gene STARD4 and osteoarthritis.