We investigate the role of miRNAs in RA pathogenesis, particularly in Treg/Th17 and M1/M2 balance, Mo-DC-cell-induced Th17 cell differentiation, the NF-kB/NLRP3 signaling pathway and neovascular dysfunction, as well as in FLS-cell-mediated energy metabolism disorder, apoptosis resistance, osteogenesis and mobility. Here, NFKB1 is linked to rheumatoid arthritis.