In contrast, it appeared that the APOE protein, that is currently documented in AD research [43], showed: (1) Spontaneous cytoplasmic and perinuclear localization of APOE protein in the 10 AD fibroblasts tested, similar to fibroblasts provided from some other neurodegenerative or aging syndromes, when observed with anti-APOE immunofluorescence (Figure 7A). Here, APOE is linked to Alzheimer disease.