APOE and Alzheimer disease: Four observations consolidated our hypothesis: (1) APOE was found spontaneously more expressed in all the AD fibroblasts tested than in the controls (Figure 8B), (2) a partnership between ATM and APOE may occur through SQ/TQ phosphorylation (Figure 8), (3) PLA data suggested that some ATM-APOE complexes may be found close to the nuclear membrane (Figure 7C), and (4) the localization of the phosphospecific forms of the APOE (pAPOE) was consistent with the ATM–pAPOE interaction (Figure 7C,D).