CHEK1 and hepatocellular carcinoma: Recently, it has been shown that simultaneous inhibition of the central coordinator of the DNA damage response (DDR), checkpoint kinase 1 (CHK1), e.g., by Chekin, and inhibition of the previously discussed epigenetic regulator BRD4, e.g., by JQ1, can be an effective and specific suppressor of HCC progression in vitro [103,176,177].