In gastric cancer (GC), since miR-3648 represses the WNT/β-catenin pathway via the inhibition of GSK-3-binding FRAT1/2 proto-oncogenes, its downregulation resulted in the upregulation of the WNT/β-catenin pathway, followed by the overexpression of MYC as a downstream effector. The gene discussed is FRAT1; the disease is gastric cancer.