This includes leukocyte chemotaxis in response to CCR2 trafficking [25], breast cancer cell invasion and metastasis in response to EGFR internalization [15,26], VEGFR2 internalization and signaling in developmental angiogenesis [120], ephrin/Eph mediated fibroblast repulsion via Eph receptor internalization [126], and potentially other situations, in which Ena/VASP proteins were implicated in attractive or repulsive guidance cue signaling [30,59,60,229,230]. This evidence concerns the gene ENAH and breast carcinoma.