When compared to white matter from individuals with Alzheimer’s disease (AD) (Figure 2G; n = 6), and non-neurologic controls (Figure 2H,I; n = 10), the number of cells with TMEM106B+ puncta were increased/×63 fields in RRMS plaques (8.65 ± 3.64; median ± SEM; n = 6), compared to AD white matter cases showing fewer than 3 cells/×63 white matter field (1.35 ± 0.326; median ± SEM; n = 6), in 30 random fields/individual examined (Figure 2K). The gene discussed is TMEM106B; the disease is early-onset autosomal dominant Alzheimer disease.