The ABCB5-positive fraction also has an upregulation of Histamine Receptor 1 (HRH1), which regulates allergic responses in nasal [78] and corneal [79,80] epithelial cells, while non-competitive histamine antagonist (H1-receptor) is proposed for the treatment of allergy affecting the ocular surface [81]. The gene discussed is HRH1; the disease is Allergy.