MAPT and Alzheimer disease: Animal models of streptozotocin (STZ)-induced hyperglycemia/diabetes or neurotoxicity mimic several histopathological hallmarks of AD, including oxidative stress, inflammation, extracellular amyloid-β (Aβ) accumulation, increased intracellular tau protein phosphorylation (p-tau), and loss of cognitive behavior [2,4,5,6,7,8].