Saito R. et al. described the first subtype-specific murine models of bladder cancer and show that Upk3a-CreERT2, Trp53L/L, PtenL/L, Rosa26LSL-Luc (UPPL, luminal-like), and BBN (basal-like) tumors are more faithful to human bladder cancer than the widely used MB49 [66]. Here, UPK3A is linked to urinary bladder cancer.