Schneiner et al. also demonstrated a predictive role of the FVIII/PC ratio in the development of acute on chronic liver failure (ACLF) in patients with decompensated advanced chronic liver disease (ACLD); moreover, FVIII/PC provided prognostic information independently of the chronic liver failure (CLIF) score: patients were stratified according to a cut-off for ACLF development (FVIII/PC > 4.46): patients who presented a baseline level of FVIII/PC > 4.46 presented a higher risk of ACLF development during follow-up [125]. This evidence concerns the gene F8 and acute-on-chronic liver failure.