PSMB5 and fragile X-associated tremor/ataxia syndrome: The PM carriers can present with (i) neuropsychiatric conditions recognized as fragile X-associated neuropsychiatric disorders (FXAND) [2], (ii) conditions leading to fertility problems and early menopause in females, named fragile X-associated primary ovarian insufficiency (FXPOI) [3], and (iii) early onset of a neurodegenerative disorder named fragile X-associated tremor/ataxia syndrome (FXTAS) [4], which all fall under the umbrella of Fragile X premutation-associated conditions (FXPAC).