SASP markers (detected in serum of AMD patients): IL-6, IL-8, IL-12, MCP-1, TNF-α, IL-1α, IL-1β, and IL-17, IL-22 [43,44].Plasma: elevated levels of C3a and CRP [94,95,96]. This evidence concerns the gene CXCL8 and age-related macular degeneration.