Higher peripheral monocyte counts [119].Reduced monocyte phagocytic function across monocyte subtypes [73].Increased activated monocytes associated with elevated TNF-α levels [120].Elevated IL-17RC expression by CD14+ monocytes—role for IL-17 in AMD [121].Impaired cholesterol efflux in senescent macrophages [104].Circulating and infiltrating monocyte/macrophage SASP markers: IL-1α, IL1-β, IL-6, IL-8, IL-12, TNF-α, C3, CFB, CXCL1, TGF-β and nitric oxide [43,65]. The gene discussed is CXCL8; the disease is age-related macular degeneration.