SASP has been associated with AMD because a number of pro-inflammatory cytokines have been detected systemically (in the serum) or locally (in the aqueous humor) of AMD patients, including IL-6, IL-8, IL-12, MCP-1, TNF-α, IL-1α, IL-1β, and IL-17 [43,44]. The gene discussed is IL1B; the disease is age-related macular degeneration.