CHIP refers to an age-related abnormal clonal expansion of hematopoietic stem cells carrying somatically acquired mutations that confer a growth advantage (observed in around 10% of people older than 65 years lacking hematologic disorders) [140], which has been linked to an increased all-cause mortality, due mostly to a higher incidence of cardiovascular diseases, other than been associated with a slightly increased risk of hematologic malignancies [140,141]. Here, STUB1 is linked to cardiovascular disorder.