Given the association of the newer-generation TKIs with cardiovascular diseases (especially in patients with pre-existing risk factors) [37,38,208] and the prognostic impact of comorbidities on CML survival, a better definition of the role of CHIP mutations in CML is worthy of further exploration for an improved management of the lifelong TKI algorithm. Here, STUB1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.