PDCD1 and non-small cell lung carcinoma: ULK1 inhibition (MRT68921) or lysosomal function impairment (CQ) blocked the autophagic degradation of immunoproteasome constituents, successfully restoring antigen presentation and leading to increased T cell infiltration and improving the response to anti-PD-1 treatment in an LKB1 mutant NSCLC mouse model.