For example, fusion of an anti-HER-2/neu peptide mimetic to Tat and a signal transducers and activators of transcription 3 (STAT3)-inhibiting peptide successfully decreased nonspecific uptake and increased specific uptake into ErbB2/HER2 positive cancer cells, which was accompanied by inhibited tumor growth in mouse xenografts [246]. This evidence concerns the gene STAT3 and cancer.