Compromised membrane fluidity can in turn aggravate impaired insulin resistance by inhibiting secretion of insulin- or GLUT-containing secretory granules [173,174,175], impaired insulin receptor signaling [176,177,178,179,180] and increased membrane packing in the ER inducing ER stress leading to further saturated lipid synthesis [181,182,183]. This evidence concerns the gene INSR and Insulin resistance.