Oxidative stress and inflammation are central to AMD pathogenesis, and it has been shown they significantly alter the RPE secretome, resulting in increased secretion of pro-angiogenic factors and decreased anti-inflammatory factors including complement factor H (CFH), a critical inhibitor of complement activation and inflammation, and the strongest genetic risk for AMD [34,35,36,37,38,39]. Here, CFH is linked to age-related macular degeneration.