ACHE and Alzheimer disease: For instance, clinically approved drugs for Alzheimer’s Disease (AD) are represented by acetylcholinesterase inhibitors such as donepezil, rivastigmine, and galantamine, aimed to restore early deficits of the subcortical cholinergic system [7]; and N-Methyl-D-Aspartate receptor antagonist (memantine), which prevents glutamate-induced excitotoxicity [8].