METTL3 and arteriovenous malformations of the brain: DTX3L has also been found up-regulated by METTL3, an RNA N6-methyladenosine (m6A) transferase [65] In particular, downregulation of the METTL3-DTX1/DTX3L dimer axis, upregulates NOTCH signaling, impairs angiogenesis in vitro, and correlates with cerebral arteriovenous malformations [65].